Effects of Deuterium Depletion on Age-Declining Thymopoiesis In Vivo
The thymus provides maturation and migration of T cells to peripheral organs of immunity,
where they recognize diverse antigens and maintain immunological memory and self-tolerance.
The thymus is known to be involved with age and in response to stress factors. Therefore, the search for approaches to the restoration of thymopoiesis is of great interest. The present investigation was aimed at evaluating how prolonged deuterium depletion affects morphogenetic processes and the physiological transition of the thymus to age-related involution. (…)
The reactive response to deuterium depletion was a sharp increase in the number of progenitor CD4−CD8− cells and The increase in the number of thymic progenitor cells after 3–4 weeks suggests consideration of deuterium elimination as a novel approach to prevent thymus involution
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Effects of Deuterium Depletion on Age-Declining Thymopoiesis In Vivo
Academic Editor: Gábor Somlyai
Citation: Nataliya V. Yaglova, Sergey S. Obernikhin, Ekaterina P. Timokhina, Dibakhan A. Tsomartova, Valentin V. Yaglov, Svetlana V. Nazimova, Elina S. Tsomartova, Marina Y. Ivanova, Elizaveta V. Chereshneva, Tatiana A. Lomanovskaya.
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